CSF Immunoglobulin G (IgG) Index

CSF stands for cerebrospinal fluid. IgG stands for immunoglobulin G. It is a type of antibody.

Antibodies are proteins that your immune system makes to fight germs. A CSF IgG index measures the levels of IgG in your cerebrospinal fluid. CSF is a clear, colorless fluid that flows in and around your brain and spinal cord.

Your brain and spinal cord make up your central nervous system. Cerebrospinal fluid cushions your central nervous system from impact or injury. It also removes waste products from the brain and helps your central nervous system work right.

Normally you have a tiny amount of IgG in your cerebrospinal fluid. High levels of IgG may mean you have an infection or an inflammatory or autoimmune disease that involves your central nervous system. An autoimmune disorder causes your immune system to attack your own healthy cells by mistake, which can lead to serious health problems.

Why this test is done

You may need a CSF IgG index if you have symptoms of a central nervous system disorder, especially multiple sclerosis (MS). The symptoms of MS often vary. They may come and go or steadily get worse.

They include:

• Blurred or double vision
• Tingling, numbness, or pain in the arms, legs, body, or face
• Painful muscle spasms
• Weak muscles, often in the hands and legs
• Dizziness
• Problems with balance and walking
• Bladder control problems
• Fatigue
• Problems with thinking or memory

How to prepare

You don't need any special preparations for a CSF IgG index, but you may be asked to empty your bladder (pee) and bowels (poop) before the test.

Sample type

CSF

Other names for this test

cerebrospinal fluid IgG level, cerebrospinal fluid IgG measurement, CSF IgG level, IgG (Immunoglobulin G) spinal fluid, IgG synthesis rate